The injury-ravaged Philadelphia 76ers (23-46) roll into the Frost Bank Center to face a San Antonio Spurs (29-39) team that's been lighting up scoreboards with the NBA's top-ranked March offense despite missing Victor Wembanyama.

While Quentin Grimes has been a lone bright spot for Philly, dropping 28.5 points per game over his last ten outings including a 46-point explosion against Houston, the Sixers' 28th-ranked defense has been hemorrhaging 130 points per game during their recent slide.

The stage is set for what could be an offensive showcase as the home team Spurs, winners of three of their last five, take on the visiting Sixers who've dropped 17 of their previous 20 games.

San Antonio Spurs vs. Philadelphia 76ers prediction: who will win?

For tonight's San Antonio Spurs vs Philadelphia 76ers matchup, our predictive model gives the Spurs a 61.67% chance of defeating the Sixers.

San Antonio Spurs: 61.67% win probability

  • Better recent form (WLWLW compared to Sixers' LLWLL)
  • Higher scoring efficiency (7768 points in 68 games vs 7580 points in 69 games)
  • Superior defensive record (7920 points against vs 7952 points against)

Philadelphia 76ers: 38.33% win probability

  • Poor road performance (23-46 overall record)
  • Offensive struggles (averaging 109.8 points per game)
  • Negative momentum (lost 3 of last 5 games)

At Sporting Post, our unique prediction model brings together insights from top NBA experts. Instead of searching through countless expert analyses online, you can rely on our predictions to capture the market's overall sentiment. We scan trusted sources, analyzing expert picks, data, and trends, while our AI assigns a confidence level to each prediction. These confidence levels are then averaged to generate an 'expert opinion' win probability—providing a data-driven reflection of the collective intelligence of the industry's leading NBA analysts.

San Antonio Spurs vs. Philadelphia 76ers odds

Here are the latest odds for this NBA matchup as the Philadelphia 76ers head to San Antonio to face the home team Spurs on Friday, March 21.

San Antonio SpursPhiladelphia 76ers
Moneyline-218 (via DraftKings Sportsbook)+185 (via Caesars Sportsbook)

San Antonio Spurs vs. Philadelphia 76ers preview

The struggling 76ers limp into San Antonio's Frost Bank Center missing nearly their entire starting lineup, with Joel Embiid, Paul George, and Andre Drummond all sidelined for the season.

There's been one bright spot in Philly's darkness though - Quentin Grimes has been absolutely lighting it up, dropping 46 against Houston last week and averaging nearly 29 points over his last ten games.

The Spurs aren't exactly having a dream season either, but they've found their offensive groove lately, leading the NBA in offensive rating this month despite losing Victor Wembanyama.

Sandro Mamukelashvili has emerged as an unlikely hero for San Antonio, coming off a ridiculous 34-point performance on 13-of-14 shooting against the Knicks.

While both teams are playing some seriously questionable defense (they're both bottom-three in March), their recent matchups have been turning into absolute scoring festivals.

The last time these teams met in December, Philly squeaked out a 111-106 win, but that was with a very different-looking Sixers squad.

With the Spurs finding their rhythm at home (18-16) and the Sixers struggling mightily on the road (11-24), this Friday night showdown could get ugly for the visitors.

Keep an eye on the Grimes-Mamukelashvili scoring duel - it might not be the star matchup we expected this season, but it's the one we've got.

Key stats

  • 1
    Spurs sit 13th in Western Conference with 29-39 record while 76ers rank 12th in East at 23-46
  • 2
    76ers carry a concerning LLWLL form streak versus Spurs' more stable WLWLW recent performance
  • 3
    Spurs hold offensive edge scoring 7768 points to 76ers' 7580 through similar games played
  • 4
    San Antonio's -152 point differential significantly better than Philadelphia's -372 on the season

San Antonio Spurs vs. Philadelphia 76ers form

San Antonio Spurs
San Antonio Spurs
Latest matches
W
L
W
L
W
Victories
3/5 (60%)
Defeats
2/5 (40%)
Mar 20, 2025
New York Knicks105:120San Antonio Spurs
Mar 18, 2025
Los Angeles Lakers125:109San Antonio Spurs
Mar 16, 2025
New Orleans Hornets115:119San Antonio Spurs
Mar 15, 2025
Charlotte Bobcats145:134San Antonio Spurs
Mar 13, 2025
Dallas Mavericks116:126San Antonio Spurs
Philadelphia 76ers
Philadelphia 76ers
Latest matches
L
L
W
L
L
Victories
1/5 (20%)
Defeats
4/5 (80%)
Mar 20, 2025
Oklahoma City Thunder133:100Philadelphia 76ers
Mar 18, 2025
Houston Rockets144:137Philadelphia 76ers
Mar 16, 2025
Dallas Mavericks125:130Philadelphia 76ers
Mar 14, 2025
Indiana Pacers112:100Philadelphia 76ers
Mar 12, 2025
Toronto Raptors118:105Philadelphia 76ers

San Antonio Spurs vs. Philadelphia 76ers head to head

San Antonio Spurs

17%

Philadelphia 76ers

83%

Dec 24, 2024

Philadelphia 76ers

111 : 106

San Antonio Spurs

Jul 20, 2024

San Antonio Spurs

80 : 96

Philadelphia 76ers

Apr 7, 2024

San Antonio Spurs

126 : 133

Philadelphia 76ers

Jan 23, 2024

Philadelphia 76ers

133 : 123

San Antonio Spurs

Feb 4, 2023

San Antonio Spurs

125 : 137

Philadelphia 76ers

Oct 22, 2022

Philadelphia 76ers

105 : 114

San Antonio Spurs